Preclinical Services
NorthernBio offers CNS delivery, toxicology, and gene/cell therapy expertise to accelerate the development and evaluation of your therapeutic.
Preclinical Expertise in CNS Delivery
NorthernBio offers services to support the development of CNS-targeted therapeutics, including neurodegenerative disease, psychiatric disorders, and chronic pain programs. By leveraging MRI-guided imaging and precision neurosurgical models, and using delivery approaches suited to hard-to-reach CNS targets, NorthernBio is able to accelerate programs from concept to regulatory approval.
Consult a Scientist
We are a team of scientists who value open communication and collaboration. We work closely with our sponsors to provide customized solutions and expert support.
Targeted CNS Delivery
NorthernBio supports intrathecal, intracerebroventricular, intraparenchymal, intracisternal, convection-enhanced, epidural, and direct CNS infusion approaches to assess biodistribution, toxicological, and efficacious effects across the blood-brain barrier, promoting better patient outcomes.
Instrumentation & Capabilities
Equipment
MRI – Philips 3T
Philips Intellispace Image Analysis
Custom MRI-compatible stereotaxic frames
Routes of Administration
Intrathecal
Intracerebroventricular (ICV)
Intraparenchymal
Intracisternal (ICM)
Convection-enhanced delivery (CED)
Epidural / perineural
Neural implants
Species
Mouse
Rat
Rabbit
Canine
Sheep
Swine
NHP
Preclinical Expertise in Toxicology & Gene/Cell Therapy
NorthernBio offers services to support IND-enabling toxicology and gene/cell therapy programs. This may include general and repeat-dose GLP toxicology, AAV biodistribution, and vector shedding studies, amongst others. By pairing GLP-compliant study design with independent quality assurance oversight, NorthernBio is able to accelerate programs from concept to regulatory approval.
Targeted Toxicology & Gene Therapy Support
NorthernBio supports the development of diverse therapeutic modalities, including stem cells, biologics, gene therapies (AAVs), RNA-based treatments, and small molecules. GLP-compliant toxicology and biodistribution studies, reviewed by an independent quality assurance unit, help sponsors build the regulatory-ready package an IND filing requires.
Instrumentation & Capabilities
Study Types
IND-enabling and GLP toxicology (single-dose and repeat-dose)
General and regulatory toxicology
AAV vector biodistribution and shedding
Gene therapy toxicology and biodistribution
Cell and gene therapy IND-enabling packages
Oligonucleotide and RNA therapeutic preclinical studies
Regulatory Framework
GLP compliance (21 CFR Part 58)
Electronic records compliance (21 CFR Part 11)
Independent, RQAP-GLP credentialed quality assurance unit
Species
Mouse
Rat
Swine
NHP
Partner With Us
Let’s work together to develop
life-changing treatments.
Join us in the pursuit of better lives through scientific innovation. Explore how NorthernBio can help you achieve your research goals, from CNS delivery through toxicology and gene therapy.